Performance of the BD ProbeTec ET direct detection assay for the analysis of Mycobacterium tuberculosis in respiratory and non-respiratory clinical specimens
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    • Taibah University Scientific Journals | المجلات العلمية في جامعة طيبة
    • Taibah University Journal for Medical Science | مجلة جامعة طيبة للعلوم الطبية
    • Volume 12 Issue 4, 2017
    • عرض المادة
    •   طيبة
    • Taibah University Scientific Journals | المجلات العلمية في جامعة طيبة
    • Taibah University Journal for Medical Science | مجلة جامعة طيبة للعلوم الطبية
    • Volume 12 Issue 4, 2017
    • عرض المادة
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    Performance of the BD ProbeTec ET direct detection assay for the analysis of Mycobacterium tuberculosis in respiratory and non-respiratory clinical specimens

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    التاريخ
    2017-08-01
    المؤلف
    Somily, Ali M.
    Habib, Hanan A.
    Sarwar, Mohammed S.
    Al-Beeshi, Nourah Z.
    Alohali, Rawa M.
    Shakoor, Zahid A.
    واصفات البيانات
    عرض سجل المادة الكامل
    الخلاصة
    Early detection of Mycobacterial tuberculosis infection (MTB) is pivotal for the treatment of tuberculosis (TB). Background: This study was performed to evaluate the performance of BD ProbeTec ET direct detection assay (DTB) against the gold standard culture technique for confirmation of MTB infection. Methods: A total of 266 consecutive and non-duplicate clinical specimens for detection of MTB were included in this study. There were 118 respiratory and 148 nonrespiratory samples. All samples were tested by microscopy for acid-fast bacillus (AFB), MTB culture and biochemical identification with simultaneous testing by DTB. Results: A total of 88 samples (33%) were culturepositive for MTB including 39/118 respiratory, 29/99 fluid and 20/49 tissue samples. DTB sensitivity for respiratory samples was 97% and specificity was 96% with a positive predictive value (PPV) of 93% and negative predictive value (NPV) of 99%. Sensitivity of DTB in fluid samples was 80%, specificity 88%, PPV 69% and NPV 93% whereas sensitivity of DTB for tissue samples was 25%, specificity 90%, PPV 63% and NPV 63%. Of the 50 (56.8%) smear-positive samples, DTB sensitivity was 100% for respiratory, 85% for fluid and 100% for tissue samples. Conclusion: DTB performed within acceptable limits for the rapid detection of MTB in respiratory samples compared to fluid and tissue specimens.
    المكان (URI)
    http://repository.taibahu.edu.sa/123456789/18161
    نوع المادة
    مقاله
    الناشر
    Journal of Taibah University Medical Sciences
    الموضوع
    Acid-fast bacillusMycobacterium tuberculosis
    اللغة
    en
    حاويات
    • Volume 12 Issue 4, 2017 [14]

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    جميع حقوق المستودع محفوظة © 2016  جامعة طيبة
    اتصل بنا | ارسال ملاحظة
    تركيب وتعريب واستضافة ودعم  @mire NV